The Immunological Genome Project (ImmGen) is a collaborative effort among leading immunology and computational biology labs dedicated to uncovering the complexities of gene activity and regulation within the immune system of the mouse. By identifying gene expression patterns, regulatory elements, and their connectivity, ImmGen provides insights into how genes are controlled during immune cell differentiation and activation, influenced by factors like genetic variation and immune challenges.
Through extensive data collection and analysis, ImmGen supports the computational reconstruction of the genetic regulatory network that drives immune cell behavior. Primarily intended as a public resource, ImmGen makes its data and metadata freely accessible, offering valuable tools for researchers worldwide to further our understanding of immune system regulation.
Key Features of the Immunological Genome Project:
Collaborative Research: Brings together expertise from immunology and computational biology for comprehensive insights.
Gene Expression Signatures: Defines specific gene activity patterns associated with immune system functions.
Regulatory Element Mapping: Identifies and maps key genomic regions controlling gene expression in immune cells.
Data Accessibility: Provides public access to all data and metadata, encouraging open research and discoveries.
Computational Reconstruction: Supports advanced modeling of genetic networks in immune cells.
